Quality by Design Methodology for Development and Scale-up of Batch Mixing Processes

Author:

Portillo Patricia M.,Ierapetritou Marianthi,Tomassone Silvina,Mc Dade Christine,Clancy Donald,Avontuur Petrus P. C.,Muzzio Fernando J.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmaceutical Science

Reference36 articles.

1. Mehrotra A, Chaudhuri B, Faqih A, Tomassone MS, Muzzio FJ. A modeling approach for understanding effects of powder flow properties on tablet weight variability. Powder Technol. 2008. doi: 10.1016/j.powtec.2008.05.016 (in press).

2. James MN. Design, manufacture and materials; their interaction and role in engineering failures. Eng Fail Anal 2005;12:662–78.

3. Alexander AW, Muzzio FJ. Batch size increase in dry blending and mixing. In: Levin M, editor. Pharmaceutical process scale-up. New York: Marcel Dekker; 2001.

4. Hassanpour A, Antony SJ, Ghadiria M. Effect of size ratio on the behaviour of agglomerates embedded in a bed of particles subjected to shearing: DEM analysis. Chem Eng Sci 2007;62(4):935–42.

5. Llusa M, Muzzio F. The effect of shear mixing on the blending of cohesive lubricants and drugs, Pharmaceutical Technology, http://pharmtech.findpharma.com/pharmtech/Mixing+and+blending/The-Effect-of-Shear-Mixing-on-the-Blending-of-Cohe/ArticleStandard/Article/detail/283906 . Accessed 1 Oct 2008; 2005.

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