Integrating Design of Experiments and Principal Component Analysis to Reduce Downstream Cost of Goods in Monoclonal Antibody Production-Reference-Cited by-同舟云学术

Integrating Design of Experiments and Principal Component Analysis to Reduce Downstream Cost of Goods in Monoclonal Antibody Production

Published:2016-11-28 Issue:4 Volume:11 Page:352-361
ISSN:1872-5120
Container-title:Journal of Pharmaceutical Innovation
language:en
Short-container-title:J Pharm Innov

Author:

Li Ying Fei,Venkatasubramanian Venkat^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmaceutical Science

Link

http://link.springer.com/content/pdf/10.1007/s12247-016-9263-8.pdf

Reference13 articles.

1. Reichert JM, Rosensweig CJ, Faden LB, Dewitz MC. Monoclonal antibody success in the clinic. Nat Biotechnol. 2005;23:1073–8.

2. Zider A, Drakeman DL. The future of monoclonal antibody technology. MAbs. 2010;2(4):361–4.

3. Costioli MD, Guillemot-Potelle C, Mitchell-Logean C, Broly H. Cost of goods modeling and quality by design for developing cost-effective processes. BioPharm Int. 2010;23(6):26–35.

4. Kelley B. Industrialization of mAb production technology the bioprocessing industry at a crossroads. MAbs. 2009;1:443–52.

5. Sommerfeld S, Strube J. Challenges in biotechnology production—generic processes and process optimization for monoclonal antibodies. Chem Eng Proc. 2005;44:1123–37.

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