Pharmacokinetics of Eltrombopag in Healthy Chinese Subjects and Effect of Sex and Genetic Polymorphism on its Pharmacokinetic and Pharmacodynamic Variability-Reference-Cited by-同舟云学术

Pharmacokinetics of Eltrombopag in Healthy Chinese Subjects and Effect of Sex and Genetic Polymorphism on its Pharmacokinetic and Pharmacodynamic Variability

Published:2021-03-29 Issue:3 Volume:46 Page:427-436
ISSN:0378-7966
Container-title:European Journal of Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Eur J Drug Metab Pharmacokinet

Author:

Chen Jinliang^ORCID,Xu Yichao,Lou Honggang,Jiang Bo,Shao Rong,Yang Dandan,Hu Yin,Ruan Zourong

Funder

National Major Science and Technology Projects of China

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Link

https://link.springer.com/content/pdf/10.1007/s13318-021-00682-4.pdf

Reference27 articles.

1. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009;113(11):2386–93. https://doi.org/10.1182/blood-2008-07-162503.

2. Matthys G, Park JW, McGuire S, Wire MB, Bowen C, Williams D, et al. Clinical pharmacokinetics, platelet response, and safety of eltrombopag at supratherapeutic doses of up to 200 mg once daily in healthy volunteers. J Clin Pharmacol. 2011;51(3):301–8. https://doi.org/10.1177/0091270010368677.

3. Saleh MI, Melhim SB, Al-Ramadhani HM, Alzubiedi S. Bayesian population pharmacokinetic modeling of eltrombopag in chronic hepatitis C patients. Eur J Drug Metab Pharmacokinet. 2019;44(1):31–42. https://doi.org/10.1007/s13318-018-0490-x.

4. Zhang Y, Kolesar JM. Eltrombopag: an oral thrombopoietin receptor agonist for the treatment of idiopathic thrombocytopenic purpura. Clin Ther. 2011;33(11):1560–76. https://doi.org/10.1016/j.clinthera.2011.10.004.

5. Karazniewicz-Lada M, Krzyzanska D, Danielak D, Rzezniczak J, Glowka F, Slomczynski M, et al. Impact of genetic variants of selected cytochrome P450 isoenzymes on pharmacokinetics and pharmacodynamics of clopidogrel in patients co-treated with atorvastatin or rosuvastatin. Eur J Clin Pharmacol. 2020;76(3):419–30. https://doi.org/10.1007/s00228-019-02822-x.

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bioequivalence and Food Effect Assessment of Eltrombopag Olamine Tablets in Healthy Chinese Subjects: An Open, Randomized, Single‐Dose, and Two‐Period Crossover Study;Clinical Pharmacology in Drug Development;2024-07-16

2. Efficacy, Safety, and Population Pharmacokinetics of Eltrombopag in Children with Different Severities of Aplastic Anemia;The Journal of Clinical Pharmacology;2024-03-18

3. Spotlight on eltrombopag concentration in pediatric immune thrombocytopenia: A single‐center observational study in China;Pediatric Investigation;2024-01-29

4. Efficacy and Safety of Hetrombopag for Thrombocytopenia in Patients with Advanced Solid Tumors: A Retrospective Study;Journal of Clinical Pharmacy and Therapeutics;2023-12-30

5. Avatrombopag ethnic sensitivity analysis in chronic liver disease and thrombocytopenia patients: individual-level pooled analysis;Therapeutic Advances in Gastroenterology;2022-01