A Phase I, Open-Label, Mass Balance Study of [14C]-Iberdomide in Healthy Subjects

Author:

Cheng Yiming,Wang Xiaomin,Liu Liangang,Silva Jose,Thomas Michael,Li Yan

Funder

Bristol-Myers Squibb

Publisher

Springer Science and Business Media LLC

Reference19 articles.

1. Amatangelo M, Cheng Y, Pierceall W, van de Donk NW, Lonial S, Wang M, Emerson J, Hong K, Maciag P, Peluso T, Gandhi A, Thakurta A. P865: biomarker analysis to support dose optimization of iberdomide as monotherapy and in combination with standard of care treatments for multiple myeloma from a phase 1/2 trial. Hemasphere. 2022;6(Suppl):758–9. https://doi.org/10.1097/01.HS9.0000846340.95760.ac. 

2. Amatangelo M, Cheng Y, Pierceall W, van de Donk NWCJ, Lonial S, Wang M, Emerson J, Hong K, Maciag P, Peluso T, Gandhi A, Thakurta A. P-231: Biomarker analysis to support dose optimization of iberdomide (IBER) as monotherapy and in combination with standard of care treatments for multiple myeloma from a phase 1/2 trial. Clin Lymphoma Myeloma Leuk. 2022;22:S162. https://doi.org/10.1016/S2152-2650(22)00561-4.

3. Lonial S, Popat R, Hulin C, Jagannath S, Oriol A, Richardson PG, Facon T, Weisel K, Larsen JT, Minnema MC, Abdallah AO, Badros AZ, Knop S, Stadtmauer EA, Cheng Y, Amatangelo M, Chen M, Nguyen TV, Amin A, Peluso T, van de Donk N. Iberdomide plus dexamethasone in heavily pretreated late-line relapsed or refractory multiple myeloma (CC-220-MM-001): a multicentre, multicohort, open-label, phase 1/2 trial. Lancet Haematol. 2022;9(11):e822–32. https://doi.org/10.1016/s2352-3026(22)00290-3.

4. Thieblemont C, Munoz J, Tucci A, Visco C, Cartron G, Corradini P, Flinn IW, Gastinne T, Bouabdallah KK, Arcaini L, Nowakowski GS, Roulin L, Topp M, Jauhari S, Vucinic V, Martin P, Gkasiamis A, Drew J, Rao P, Kaplan M, Cheng Y, Li J, Morschhauser F. Iberdomide (CC-220) monotherapy or in combination with an anti-CD20 monoclonal antibody as effective therapy in patients with relapsed/refractory lymphoma: early results from a phase 1/2 study. Blood. 2022;140(Supplement 1):569–72. https://doi.org/10.1182/blood-2022-162559.

5. van de Donk NWCJ, Raab MS, Besemer B, Siegel DS, Anwer F, Lipe B, White D, Khan A, Pianko MJ, Cheng Y, Chen L, Lin H, Maciag P, Emerson J, Amin A, Lonial S. P-279: Efficacy, safety, and pharmacokinetics of iberdomide plus dexamethasone in patients with relapsed/refractory multiple myeloma by renal function: a subgroup analysis of the CC-220-MM-001 trial. Clin Lymphoma Myeloma Leuk. 2022;22:S191–2. https://doi.org/10.1016/S2152-2650(22)00609-7.

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