Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction-Reference-Cited by-同舟云学术

Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction

Published:2020-09-15 Issue:6 Volume:45 Page:761-770
ISSN:0378-7966
Container-title:European Journal of Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Eur J Drug Metab Pharmacokinet

Author:

Chen Jinliang^ORCID,Xu Yichao,Lou Honggang,Jiang Bo,Shao Rong,Yang Dandan,Hu Yin,Ruan Zourong

Funder

National Major Science and Technology Projects of China

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Link

https://link.springer.com/content/pdf/10.1007/s13318-020-00647-z.pdf

Reference24 articles.

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2. Tanaka C. Clinical pharmacology of deferasirox. Clin Pharmacokinet. 2014;53(8):679–94. https://doi.org/10.1007/s40262-014-0151-4.

3. Waldmeier F, Bruin GJ, Glaenzel U, Hazell K, Sechaud R, Warrington S, et al. Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state. Drug Metab Disposit Biol Fate Chem. 2010;38(5):808–16. https://doi.org/10.1124/dmd.109.030833.

4. Cappellini MD, Bejaoui M, Agaoglu L, Canatan D, Capra M, Cohen A, et al. Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up. Blood. 2011;118(4):884–93. https://doi.org/10.1182/blood-2010-11-316646.

5. Sechaud R, Dutreix C, Balez S, Pommier F, Dumortier T, Morisson S, et al. Relative bioavailability of deferasirox tablets administered without dispersion and dispersed in various drinks. Int J Clin Pharmacol Ther. 2008;46(2):102–8. https://doi.org/10.5414/cpp46102.

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