Drug Evaluation: The Combination of Fenofibrate and Simvastatin for the Treatment of Dyslipidemia: When and for Whom?

Author:

Nikolic Dragana,Katsiki Niki,Toth Peter P.,Banach Maciej,Al-Waili Khalid,Al-Rasadi Khalid,Rizzo Manfredi,Mikhailidis Dimitri P.

Publisher

Springer International Publishing

Reference45 articles.

1. Agouridis AP, Rizos CV, Elisaf MS, Filippatos TD. Does combination therapy with statins and fibrates prevent cardiovascular disease in diabetic patients with atherogenic mixed dyslipidemia? Rev Diabet Stud. 2013;10(2–3):171–90. doi: 10.1900/RDS.2013.10.171 .

2. Ballantyne CM, Jones PH, Kelly MT, Setze CM, Lele A, Thakker KM, Stolzenbach JC. Long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients with persistent elevated triglycerides. Cardiovasc Drugs Ther (Sponsored by the International Society of Cardiovascular Pharmacotherapy). 2011;25(1):59–67. doi: 10.1007/s10557-011-6280-1 .

3. Barylski M, Toth PP, Nikolic D, Banach M, Rizzo M, Montalto G. Emerging therapies for raising high-density lipoprotein cholesterol (HDL-C) and augmenting HDL particle functionality. Best Pract Res Clin Endocrinol Metab. 2014;28(3):453–61. doi: 10.1016/j.beem.2013.11.001 .

4. Bays HE, Roth EM, McKenney JM, Kelly MT, Thakker KM, Setze CM, Obermeyer K, Sleep DJ. The effects of fenofibric acid alone and with statins on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. Diabetes Care. 2010;33(9):2113–6. doi: 10.2337/dc10-0357 .

5. Bergman AJ, Murphy G, Burke J, Zhao JJ, Valesky R, Liu L, Lasseter KC, He W, Prueksaritanont T, Qiu Y, Hartford A, Vega JM, Paolini JF. Simvastatin does not have a clinically significant pharmacokinetic interaction with fenofibrate in humans. J Clin Pharmacol. 2004;44(9):1054–62. doi: 10.1177/0091270004268044 .

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1. Conclusions and Take Home Message;Combination Therapy In Dyslipidemia;2015

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