The Role of Pharmacometrics in the Development of Antimicrobial Agents

Author:

Bader Justin C.,Lakota Elizabeth A.,VanScoy Brian,Bhavnani Sujata M.,Ambrose Paul G.

Publisher

Springer International Publishing

Reference67 articles.

1. Boucher HW, Ambrose PG, Chambers HF, Ebright RH, Jezek A, Murray BE, Newland JG, Ostrowsky B, Rex JH. White paper: Developing antimicrobial drugs for resistant pathogens, narrow-spectrum indications, and unmet needs. J Infect Dis. 2017;216:228–36.

2. Bulik CC, Bhavnani SM, Hammel JP, Forrest A, Dudley MN, Ellis-Grosse EJ, Drusano GL, Ambrose PG. Evaluation of the probability of regulatory approval based on pre-clinical pharmacokinetic-pharmacodynamic target attainment for community-acquired bacterial and hospital-acquired bacterial pneumonia. In: Abstracts of the Interscience conference on antimicrobial agents and chemotherapy, Denver, September 10–13, 2013. Abstract A-295.

3. Ambrose PG, Bhavnani SM, Rubino CM, Louie A, Gumbo T, Forrest A, Drusano GL. Pharmacokinetics-pharmacodynamics of antimicrobial therapy: It's not just for mice anymore. Clin Infect Dis. 2007;44:79–86.

4. Ambrose PG. Antibacterial drug development program successes and failures: a pharmacometric explanation. Curr Opin Pharmacol. 2017;36:1–7.

5. United States Department of Health and Human Services, Food and Drug Administration. Guidance for Industry. Acute bacterial skin and skin structure infections: developing drugs for treatment. October 2013.

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