Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis
Author:
Funder
Canadian Institutes in Health Research
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Neurology (clinical),Pharmacology
Link
https://link.springer.com/content/pdf/10.1007/s13311-020-00998-0.pdf
Reference58 articles.
1. Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003;278(11):8869-72.
2. Willems MM, Zom GG, Meeuwenoord N, Khan S, Ossendorp F, Overkleeft HS, et al. Lipophilic Muramyl Dipeptide–Antigen Conjugates as Immunostimulating Agents. ChemMedChem. 2016;11(2):190-8.
3. Grimes CL, Ariyananda LDZ, Melnyk JE, O’Shea EK. The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment. J Am Chem Soc 2012;134(33):13535-7.
4. Kim Y-G, Kamada N, Shaw MH, Warner N, Chen GY, Franchi L, et al. The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity. 2011;34(5):769-80.
5. Philpott DJ, Sorbara MT, Robertson SJ, Croitoru K, Girardin SE. NOD proteins: regulators of inflammation in health and disease. Nat Rev Immunol 2014;14(1):9.
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