Bicalutamide and Trehalose Ameliorate Spinal and Bulbar Muscular Atrophy Pathology in Mice

Author:

Galbiati Mariarita,Meroni Marco,Boido Marina,Cescon Matilde,Rusmini Paola,Crippa Valeria,Cristofani Riccardo,Piccolella Margherita,Ferrari Veronica,Tedesco Barbara,Casarotto Elena,Chierichetti Marta,Cozzi Marta,Mina Francesco,Cicardi Maria Elena,Pedretti Silvia,Mitro Nico,Caretto Anna,Risè Patrizia,Sala Angelo,Lieberman Andrew P.,Bonaldo Paolo,Pennuto Maria,Vercelli Alessandro,Poletti AngeloORCID

Funder

Fondazione Telethon

Kennedy's Disease Association

Fondazione Cariplo

Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica

AFM-Téléthon

Università degli Studi di Milano

Ministero dell’Istruzione, dell’Università e della Ricerca

Agenzia Italiana del Farmaco, Ministero della Salute

EU Joint Programme – Neurodegenerative Disease Research

Publisher

Elsevier BV

Subject

Pharmacology (medical),Neurology (clinical),Pharmacology

Reference80 articles.

1. Molecular pathogenesis of spinal bulbar muscular atrophy (Kennedy's disease) and avenues for treatment;Grunseich;Curr Opin Neurol,2020

2. Molecular mechanisms and therapeutics for SBMA/Kennedy's disease;Arnold;Neurotherapeutics,2019

3. Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy;Cortes;Neuron,2014

4. Deterioration of muscle force and contractile characteristics are early pathological events in spinal and bulbar muscular atrophy mice;Gray;Dis Model Mech.,2020

5. Spinal and bulbar muscular atrophy: a motoneuron or muscle disease?;Jordan;Curr Opin Pharmacol,2008

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