A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition-Reference-Cited by-同舟云学术

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A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition

Published:2020-10-28 Issue:1 Volume:18 Page:309-325
ISSN:1933-7213
Container-title:Neurotherapeutics
language:en
Short-container-title:Neurotherapeutics

Author:

Ibarburu Sofía,Kovacs Mariángeles,Varela Valentina,Rodríguez-Duarte Jorge,Ingold Mariana,Invernizzi Paulina,Porcal Williams,Arévalo Ana Paula,Perelmuter Karen,Bollati-Fogolín Mariela,Escande Carlos,López Gloria V.,King Peter,Si Ying,Kwon Yuri,Batthyány Carlos,Barbeito Luis,Trias Emiliano^ORCID

Funder

Fondo para la Convergencia Estructural del Mercosur

Agencia Nacional de Investigacion e Inovacion

Sistema Nacional de Investigadores

Programa de Desarrollo de Ciencias Basicas

EOLO Pharma

National Institut of Neurological Disorders and Stroke

Department of Veternas Affairs

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Neurology (clinical),Pharmacology

Link

https://link.springer.com/content/pdf/10.1007/s13311-020-00953-z.pdf

Reference63 articles.

1. Brown RH, Al-Chalabi A. Amyotrophic Lateral Sclerosis. N Engl J Med 2017;377(2):162-72. https://doi.org/10.1056/NEJMra1603471.

2. Miller RG, Mitchell JD, Lyon M, Moore DH. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Amyotroph Lateral Scler Other Motor Neuron Disord 2003;4(3):191-206.

3. Writing G, Edaravone ALSSG. Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 2017;16(7):505-12. https://doi.org/10.1016/S1474-4422(17)30115-1.

4. Howland DS, Liu J, She Y, Goad B, Maragakis NJ, Kim B, et al. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2002;99(3):1604-9. https://doi.org/10.1073/pnas.032539299.

5. Diaz-Amarilla P, Olivera-Bravo S, Trias E, Cragnolini A, Martinez-Palma L, Cassina P, et al. Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2011;108(44):18126-31. https://doi.org/10.1073/pnas.1110689108.

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