Abstract
Abstract
Objective
Updated report about the randomized comparison of the effect of radiotherapy on painful osteoarthritis (OA) applying a standard dose vs. a very low dose regime after a follow-up of 1 year.
Patients and methods
Patients presenting with OA of the hand/finger and knee joints were included. After randomization (every joint region was randomized separately) the following protocols were applied: (a) standard arm: total dose 3.0 Gy, single fractions of 0.5 Gy twice a week; (b) experimental arm: total dose 0.3 Gy, single fractions of 0.05 Gy twice a week. The dosage was blinded for the patients. For evaluation the scores after 1‑year visual analog scale (VAS), Knee Injury and Osteoarthritis Outcome Score–Short Form (KOOS-PS), Short Form Score for the Assessment and Quantification of Chronic Rheumatic Affections of the Hands (SF-SACRAH) and 12-item Short-Form Health Survey (SF-12) were used (for further details: see [1]).
Results
The standard dose was applied to 77 hands and 33 knees, the experimental dose was given to 81 hands and 30 knees. After 12 months, the data of 128 hands and 45 knees were available for evaluation. Even after this long time, we observed a favorable response of pain to radiotherapy in both trial arms; however, there were no reasonable statistically significant differences between both arms concerning pain, functional, and quality of life scores. Side effects did not occur. The only prognostic factor was the pain level before radiotherapy.
Conclusions
We found a favorable pain relief and a limited response in the functional and quality of life scores in both treatment arms. The possible effect of low doses such as 0.3 Gy on pain is widely unknown.
Funder
Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Radiology, Nuclear Medicine and imaging
Reference29 articles.
1. Niewald M, Muller LN, Hautmann MG, Dzierma Y, Melchior P, Graber S et al (2022) ArthroRad trial: multicentric prospective and randomized single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis depending on the dose-results after 3 months’ follow-up. Strahlenther Onkol 198(4):370–377. https://doi.org/10.1007/s00066-021-01866-210.1007/s00066-021-01866-2
2. Mücke RS (2013) Arthrosen der großen Gelenke der unteren Extremität. www.degro.org/ueber-uns/veroeffentlichungen/leitlinien. Accessed: 20.09.2023
3. Michael JW, Schluter-Brust KU, Eysel P (2010) The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee. Dtsch Ärztebl Int 107(9):152–162. https://doi.org/10.3238/arztebl.2010.0152
4. Jacob I (2013) Strahlentherapie bei Arthrosen der kleinen Gelenke. www.degro.org/ueber-uns/veroeffentlichungen/leitlinien. Accessed: 20.09.2023
5. Alvarez B, Montero A, Alonso R, Valero J, Lopez M, Ciervide R et al (2022) Low-dose radiation therapy for hand osteoarthritis: shaking hands again? Clin Transl Oncol 24(3):532–539. https://doi.org/10.1007/s12094-021-02710-w