DEGRO practical guideline for partial-breast irradiation

Author:

Strnad V., ,Krug D.,Sedlmayer F.,Piroth M. D.,Budach W.,Baumann R.,Feyer P.,Duma M. N.,Haase W.,Harms W.,Hehr T.,Fietkau R.,Dunst J.,Sauer R.

Abstract

Abstract Purpose This consensus statement from the Breast Cancer Working Group of the German Society for Radiation Oncology (DEGRO) aims to define practical guidelines for accelerated partial-breast irradiation (APBI). Methods Recent recommendations for relevant aspects of APBI were summarized and a panel of experts reviewed all the relevant literature. Panel members of the DEGRO experts participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for implementing APBI in clinical routine, focusing on patient selection, target definition, and treatment technique. Results Appropriate patient selection, target definition for different APBI techniques, and basic rules for appropriate APBI techniques for clinical routine outside of clinical trials are described. Detailed recommendations for APBI in daily practice, including dose constraints, are given. Conclusion Guidelines are mandatory to assure optimal results of APBI using different techniques.

Funder

Universitätsklinikum Erlangen

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Radiology, Nuclear Medicine and imaging

Reference87 articles.

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2. Coles CE, Griffin CL, Kirby AM et al (2017) Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5‑year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial. Lancet 390(10099):1048–1060

3. Polgar C, Ott OJ, Hildebrandt G et al (2017) Late side-effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: 5‑year results of a randomised, controlled, phase 3 trial. Lancet Oncol 18(2):259–268

4. Schafer R, Strnad V, Polgar C et al (2018) Quality-of-life results for accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation in early breast cancer after breast-conserving surgery (GEC-ESTRO): 5‑year results of a randomised, phase 3 trial. Lancet Oncol 19(6):834–844

5. Livi L, Meattini I, Marrazzo L et al (2015) Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5‑year survival analysis of a phase 3 randomised controlled trial. Eur J Cancer 51(4):451–463

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