Abstract
AbstractMerkel cell carcinoma (MCC) is a radiosensitive tumor and the role of radiotherapy in the management of this disease was newly defined in the recently published update of the S2k guideline on Merkel cell carcinoma of the Association of Scientific Medical Societies in Germany (AWMF). While adjuvant radiotherapy of the tumor bed is broadly recommended, irradiation of the regional nodal region can be performed in patients with negative sentinel lymph nodes and high-risk factors. In patients with positive sentinel lymph nodes, it is an alternative to completion lymphadenectomy. The standard dose for adjuvant radiotherapy remains 50 Gy.
Funder
Martin-Luther-Universität Halle-Wittenberg
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Radiology, Nuclear Medicine and imaging
Reference18 articles.
1. Becker JC, Beer AJ, DeTemple VK et al (2023) S2k Guideline - Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) - Update 2022. J Dtsch Dermatol Ges 21:305–320
2. Becker JC, Eigentler T, Frerich B et al (2019) S2k guidelines for Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin)—update 2018. J Dtsch Dermatol Ges 17:562–576
3. Bhatia S, Storer BE, Iyer JG et al (2016) Adjuvant radiation therapy and chemotherapy in Merkel cell carcinoma: survival analyses of 6908 cases from the national cancer data base. J Natl Cancer Inst 108:djw42
4. Mojica P, Smith D, Ellenhorn JDI (2007) Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin. J Clin Oncol 25:1043–1047
5. Naseri S, Steiniche T, Ladekarl M et al (2020) Management recommendations for Merkel cell carcinoma—a Danish perspective. Cancers 12:554