Author:
Schildkraut Joellen M.,Johnson Courtney,Dempsey Lauren F.,Qin Bo,Terry Paul,Akonde Maxwell,Peters Edward S.,Mandle Hannah,Cote Michele L.,Peres Lauren,Moorman Patricia,Schwartz Ann G.,Epstein Michael,Marks Jeffrey,Bondy Melissa,Lawson Andrew B.,Alberg Anthony J.,Bandera Elisa V.
Abstract
Abstract
Purpose
The causes for the survival disparity among Black women with epithelial ovarian cancer (EOC) are likely multi-factorial. Here we describe the African American Cancer Epidemiology Study (AACES), the largest cohort of Black women with EOC.
Methods
AACES phase 2 (enrolled 2020 onward) is a multi-site, population-based study focused on overall survival (OS) of EOC. Rapid case ascertainment is used in ongoing patient recruitment in eight U.S. states, both northern and southern. Data collection is composed of a survey, biospecimens, and medical record abstraction. Results characterizing the survival experience of the phase 1 study population (enrolled 2010–2015) are presented.
Results
Thus far, ~ 650 patients with EOC have been enrolled in the AACES. The five-year OS of AACES participants approximates those of Black women in the Surveillance Epidemiology and End Results (SEER) registry who survive at least 10-month past diagnosis and is worse compared to white women in SEER, 49 vs. 60%, respectively. A high proportion of women in AACES have low levels of household income (45% < $25,000 annually), education (51% ≤ high school education), and insurance coverage (32% uninsured or Medicaid). Those followed annually differ from those without follow-up with higher levels of localized disease (28 vs 24%) and higher levels of optimal debulking status (73 vs 67%).
Conclusion
AACES is well positioned to evaluate the contribution of social determinants of health to the poor survival of Black women with EOC and advance understanding of the multi-factorial causes of the ovarian cancer survival disparity in Black women.
Funder
NCI
National Cancer Institute, United States
Publisher
Springer Science and Business Media LLC
Cited by
5 articles.
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