Formation, toxicity and inactivation of acrolein during biotransformation of cyclophosphamide as studied in freshly isolated cells from rat liver and kidney

Author:

Ohno Yasuo,Ormstad Kari

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Reference19 articles.

1. Berrigan MJ, Marinello AJ, Pavelic Z, Williams CJ, Struck RF, Gurtoo HL (1982) Protective role of thiols in cyclophosphamide-induced urotoxicity and depression of hepatic drug metabolism. Cancer Res 42: 3688?3695

2. Brock N (1980) The development of mesna for the inhibition of urotoxic side effects of cyclophosphamide, ifosfamide, and other oxazaphosphorine cytostatics. In: G Mathei, FM Muggia (ededs), Cancer Chemo- and Immunopharmacology, p 274, Berlin, Springer-Verlag

3. Brock N, Stekar J, Pohl J, Niemeyer U, Scheffler G (1979) Acrolein, the causative factor of urotoxic side effects of cyclophosphamide, ifosfamide, trofosfamide and sulfosfamide. Drug Res 29: 659?661

4. Cox PJ (1979) Cyclophosphamide cystitis ? Identification of acrolein as the causative agent. Biochem Pharmacol 28: 2045?2049

5. Cox PJ, Phillips BJ, Thomas P (1975) The enzymatic basis of the selective action of cyclophosphamide. Cancer Res 35: 3755?3761

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