TCV-309, a novel platelet activating factor antagonist, inhibits leukocyte accumulation and protects against splanchnic artery occlusion shock

Author:

Canale Patrizia,Squadrito Francesco,Altavilla Domenica,Ioculano Mariapatrizia,Zingarelli Basilia,Campo Giuseppe M.,Urna Giuseppe,Sardella Aurora,Squadrito Giovanni,Capuli Achille P.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Toxicology,Pharmacology,Immunology

Reference32 articles.

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2. D. N. Granger, J. N. Benoit, M. Suzuki and M. B. Grisham,Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am. J. Physiol.257, (Gastrointest Liver Physiol 20): G683-G688 (1989).

3. P. Canale, F. Squadrito, B. Zingarelli, D. Altavilla, M. Ioculano, G. M. Campo and A. P. Caputi,Splanchnic artery occlusion shock vinblastine-induced leukopenia reduces tumor necrosis factor and thromboxane A 2 formation and increases survival rate. Pharmacol. Res.27, 1–11 (1993).

4. M. Oliver, R. D. Specian, M. A. Perry and D. N. Granger,Morphologic assessment of leukocyte-endothelial cell interaction in mesenteric venules subjected to ischemia and reperfusion. Inflammation15, 331–335 (1991).

5. L. M. Mc Manus, D. J. Hanahan, C. A. Demopoulos and R. N. Pinckard,Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine 2(AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit. J. Immunol.124, 2919–2924 (1980).

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