Treating MS After 50: the Role of Age in Therapeutic Decision-Making
Author:
Publisher
Springer Science and Business Media LLC
Subject
Clinical Neurology
Link
http://link.springer.com/content/pdf/10.1007/s11940-021-00662-8.pdf
Reference113 articles.
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3. • Wallin MT, Culpepper WJ, Campbell JD, et al. The prevalence of MS in the United States: a population-based estimate using health claims data. Neurology 2019; 92: e1029–e1040. This study provides updates in prevalence of MS in the US.
4. Mahad DH, Trapp BD, Lassmann H. Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol. 2015;14:183–93.
5. •• Sun M, McDonald SJ, Brady RD, et al. The need to incorporate aged animals into the preclinical modeling of neurological conditions. Neurosci Biobehav Rev 2020; 109: 114–128. This review highlights the biological changes of age and impact on neurological disorders and provides rationale for the need of older animals in pre-clinical trials to improve success of translation into human trials.
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