Treatment Options in Intractable Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED)
Author:
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical)
Link
http://link.springer.com/content/pdf/10.1007/s11940-015-0390-1.pdf
Reference43 articles.
1. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. International Restless Legs Syndrome Study Group. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria–history, rationale, description, and significance. Sleep Med. 2014;15:860–73. This paper provides an important description and historical overview that brings to the updated diagnostic criteria for RLS/WED.
2. Manconi M, Ferri R, Zucconi M, Oldani A, Fantini ML, Castronovo V, et al. First night efficacy of pramipexole in restless legs syndrome and periodic leg movements. Sleep Med. 2007;8:491–7. This study demonstrates the immediate efficacy and tolerability of pramipexole in RLS/WED patients.
3. Mackie S, Winkelman JW. Long-term treatment of restless legs syndrome (RLS): an approach to management of worsening symptoms, loss of efficacy, and augmentation. CNS Drugs. 2015;29:351–7.
4. Trenkwalder C, Beneš H, Grote L, García-Borreguero D, Högl B, Hopp M, et al. (2013). Prolonged release oxycodone–naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension. Lancet Neurol. 2013;12:1141–50. This study provides evidence for the employment of opioids in RLS/WED treatment when first-line drugs have no efficacy.
5. Tzonova D, Larrosa O, Calvo E, Granizo JJ, Williams AM, De la Llave Y, et al. Breakthrough symptoms during the daytime in patients with restless legs syndrome (Willis-Ekbom disease). Sleep Med. 2012;13:151–5.
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