Herpes simplex encephalitis in adults and older children
Author:
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical)
Link
http://link.springer.com/content/pdf/10.1007/s11940-005-0023-1.pdf
Reference26 articles.
1. Whitley RJ, Alford CA, Hirsh MS, et al.: Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N Engl J Med 1986, 314:144–149. This paper is proof of efficacy of acyclovir in HSE over other agents.
2. Skoldenberg B, Forsgren M, Alestig K, et al.: Acyclovir versus vidarabine in herpes simplex encephalitis: randomized multi-center study in consecutive Swedish patients. Lancet 1984, 2:707–711. This paper also provides proof of efficacy of acyclovir in HSE over other agents.
3. Whitley R, Lakeman AD, Nahmias A, Roizman B: DNA restriction enzyme analysis of herpes simplex virus isolates obtained from patients with encephalitis. N Engl J Med 1982, 307:1060–1062. This is an old but elegant study not likely to be repeated which examines whether viral isolates of the trigeminal ganglion and brain in the same patient are identical or not. It was a draw, 50% were, and 50% were not, keeping the mystery of pathogenesis alive.
4. Esiri MM: Herpes simplex encephalitis in immunohistological study of the distribution of viral antigen within the brain. J Neurol Sci 1982, 54:209–226. This study is old, but very detailed, about the virologic distribution of HSV in the brain of HSE patients.
5. Domingues RB, Lakeman FD, Mayo MS, Whitley RJ: Application of competitive PCR to cerebrospinal fluid samples from patients with herpes simplex encephalitis. J Clin Microbiol 1998, 36:2229–2234. This study shows that PCR HSV viral load in the cerebrospinal fluid correlates with the outcome of disease, and emphasizes the need for early treatment.
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