Targeted Therapies in Brain Metastases
Author:
Publisher
Springer Science and Business Media LLC
Subject
Clinical Neurology
Link
http://link.springer.com/content/pdf/10.1007/s11940-013-0276-z.pdf
Reference65 articles.
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3. Olson EM, Najita JS, Burstein HJ, Sohl J, Arnaout A, Winer EP, et al. Clinical outcomes and treatment practice patterns of patients with HER2-positive metastatic breast cancer in the post-trastuzumab era. The Breast. 2013;22(4):525–31.
4. Pestalozzi BC, Holmes E, de Azambuja E, Metzger-Filho O, Hogge L, Scullion M, et al. CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01). Lancet Oncol. 2013;14(3):244–8This study describes the incidence of CNS metastases in patients with breast cancer who have relapsed after adjuvant trastuzumab. The study confirms the low incidence of CNS as site of first relapse but demonstrates that CNS recurrences over time remain extremely common, even in the post-trastuzumab era..
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