A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine

Author:

Heal D. J.,Frankland A. T. J.,Gosden J.,Hutchins L. J.,Prow M. R.,Luscombe G. P.,Buckett W. R.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Reference28 articles.

1. Blitzer RD, Becker RE (1985) Characterization of the bupropion cue in the rat: lack of evidence for a dopaminergic mechanism. Psychopharmacology 85:173–177

2. Braestrup C (1977) Biochemical differentiation of amphetamine vs methylphenidate and nomifensine in rats. J Pharm Pharmacol 29:463–470

3. Buckett WR, Thomas PC, Luscombe GP (1988) The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog Neuropsychopharmacol Biol Psychiatry 12:575–584

4. Cheetham SC, Viggers JA, Slater NA, Buckett WR (1990) Inhibition of [3H]paroxetine binding by sibutramine, its metabolites and other antidepressants correlates with inhibition of [3H]5-hydroxytryptamine uptake. Br J Pharmacol 101:515P

5. Cooper BR, Hester TJ, Maxwell RA (1980) Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo. J Pharmacol Exp Ther 215:127–134

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