The PI3K/Akt/mTOR pathway regulates the replicative senescence of human VSMCs-Reference-Cited by-同舟云学术

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The PI3K/Akt/mTOR pathway regulates the replicative senescence of human VSMCs

Published:2016-09-13 Issue:1-2 Volume:422 Page:1-10
ISSN:0300-8177
Container-title:Molecular and Cellular Biochemistry
language:en
Short-container-title:Mol Cell Biochem

Author:

Tan Pan,Wang Yan-Jiao,Li Shuang,Wang Yi,He Je-Yu,Chen Yi-Yin,Deng Hui-Qian,Huang Wu,Zhan Jun-Kun,Liu You-Shuo

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Hunan Province Special Health Research Projects

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s11010-016-2796-9.pdf

Reference37 articles.

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2. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392–395

3. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R (2011) Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 66:191–201

4. Goldberg EL, Romero-Aleshire MJ, Ventevogel MS, Chew WM, Uhrlaub JL, Smithey MJ, Limesand KH, Sempowski GD, Brooks HL, Nikolich-Žugich J (2015) Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. Aging Cell 14:130–138

5. Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21–35

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