Testosterone deficiency accelerates early stage atherosclerosis in miniature pigs fed a high-fat and high-cholesterol diet: urine 1H NMR metabolomics targeted analysis

Author:

Deng Liqun,Fu Danting,Zhu Liang,Huang Junjie,Ling Yun,Cai ZhaoweiORCID

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine

Reference32 articles.

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2. Boden WE, Miller MG, McBride R, Harvey C, Snabes MC, Schmidt J, McGovern ME, Fleg JL, Desvigne-Nickens P, Anderson T, Kashyap M, Probstfield JL (2020) Testosterone concentrations and risk of cardiovascular events in androgen-deficient men with atherosclerotic cardiovascular disease. Am Heart J 224:65–76. https://doi.org/10.1016/j.ahj.2020.03.016

3. Wilhelmson AS, Lantero Rodriguez M, Svedlund Eriksson E, Johansson I, Fogelstrand P, Stubelius A, Lindgren S, Fagman JB, Hansson Göran K, Carlsten H, Karlsson MCI, Ekwall O, Åsa T (2018) Testosterone protects against atherosclerosis in male mice by targeting thymic epithelial cells-brief report. Arterioscler Thromb Vasc Biol 38(7):1519–1527. https://doi.org/10.1161/ATVBAHA.118.311252

4. Bourghardt J, Wilhelmson AS, Alexanderson C, De Gendt K, Verhoeven G, Krettek A, Ohlsson C, Tivesten A (2010) Androgen receptor-dependent and independent atheroprotection by testosterone in male mice. Endocrinology 151(11):5428–5437. https://doi.org/10.1210/en.2010-0663

5. Langheinrich AC, Paradowska A, Kilinski R, Kampschulte M, Steinfeld K, Altinkilic B, Steger K, Stieger P, Bergmann M, Weidner W (2012) Mixed testicular atrophy related to atherosclerosis: first lessons from the ApoE(-/-)/ LDL receptor(-/-) double knockout mouse model. Int J Androl 35(4):562–571. https://doi.org/10.1111/j.1365-2605.2011.01228.x

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