In vitro cellular uptake and neuroprotective efficacy of poly-arginine-18 (R18) and poly-ornithine-18 (O18) peptides: critical role of arginine guanidinium head groups for neuroprotection-Reference-Cited by-同舟云学术

In vitro cellular uptake and neuroprotective efficacy of poly-arginine-18 (R18) and poly-ornithine-18 (O18) peptides: critical role of arginine guanidinium head groups for neuroprotection

Published:2019-11-02 Issue:1-2 Volume:464 Page:27-38
ISSN:0300-8177
Container-title:Molecular and Cellular Biochemistry
language:en
Short-container-title:Mol Cell Biochem

Author:

MacDougall Gabriella^ORCID,Anderton Ryan S.,Ouliel Eden,Gao Junjie,Redmond Sharon L.,Knuckey Neville W.,Meloni Bruno P.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s11010-019-03646-0.pdf

Reference74 articles.

1. Meloni BP, Milani D, Edwards AB et al (2015) Neuroprotective peptides fused to arginine-rich cell penetrating peptides: neuroprotective mechanism likely mediated by peptide endocytic properties. Pharmacol Ther 153:36–54. https://doi.org/10.1016/j.pharmthera.2015.06.002

2. Meloni BP, Milani D, Cross JL et al (2017) Assessment of the neuroprotective effects of arginine-rich protamine peptides, poly-arginine peptides (R12-Cyclic, R22) and arginine–tryptophan-containing peptides following in vitro excitotoxicity and/or permanent middle cerebral artery occlusion in rats. NeuroMolecular Med 19:271–285. https://doi.org/10.1007/s12017-017-8441-2

3. Milani D, Cross JL, Anderton RS et al (2017) Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat. Neurosci Res 114:9–15. https://doi.org/10.1016/j.neures.2016.09.002

4. Edwards A, Feindel K, Cross J et al (2017) Neuroprotective efficacy of poly-arginine-18 (R18) peptides using an in vivo model of perinatal hypoxic ischaemic encephalopathy (HIE). J Cereb Blood Flow Metab 37:18–19

5. Chiu LS, Anderton RS, Cross JL et al (2019) Poly-arginine peptide R18D reduces neuroinflammation and functional deficits following traumatic brain injury in the long-evans rat. Int J Pept Res Ther. https://doi.org/10.1007/s10989-018-09799-8

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