Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K2 is associated with p53 and independent of the intrinsic apoptotic pathway

Author:

Li Lu,Qi Zhiling,Qian Jin,Bi Fuyong,Lv Jun,Xu Lei,Zhang Ling,Chen Hongyu,Jia Renbing

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine

Reference30 articles.

1. Matsumoto K, Okano J, Nagahara T et al (2006) Apoptosis of liver cancer cells by vitamin K2 and enhancement by MEK inhibition. Int J Oncol 29:1501–1508

2. Conly JM, Stein K (1992) The production of menaquinones (vitamin K2) by intestinal bacteria and their role in maintaining coagulation homeostasis. Prog Food Nutr Sci 16:307–343

3. Shiraki M, Shiraki Y, Aoki C et al (2000) Vitamin K2 (menaquinone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res 15:515–521

4. Miyazawa K, Yaguchi M, Funato K et al (2001) Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells. Leukemia 15:1111–1117

5. Yokoyama T, Miyazawa K, Yoshida T et al (2005) Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines. Int J Oncol 26:33–40

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