Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling

Author:

Li Ying,Huang Xiaohua,Zhong Weiliang,Zhang Jianing,Ma Keli

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine

Reference26 articles.

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2. Birkle S, Zeng G, Gao L, Yu RK, Aubry J (2003) Role of tumor-associated gangliosides in cancer progression. Biochimie 85:455–463

3. Hakomori S (1996) Tumor malignancy defined by aberrant glycosylation and sphingo(glyco) lipid metabolism. Cancer Res 56:5309–5318

4. Iwabuchi K, Yamamura S, Prinetti A, Handa K, Hakomori S (1998) GM3-enriched microdomain involved in cell adhesion and signal transduction through carbohydrate–carbohydrate interaction in mouse melanoma B16 cells. J Biol Chem 273:9130–9138

5. Bremer EG, Schlessinger J, Hakomori S (1986) Ganglioside-mediated modulation of cell growth: specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. J Biol Chem 261:2434–2440

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