Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function

Author:

Li Yuanjun,Liu Wen,Saini Vasu,Wong Yung H.ORCID

Funder

University Grants Committee of Hong Kong

Hong Kong Research Grants Council Theme-based Research Scheme

Innovation and Technology Commission - Hong Kong

The Hong Kong Jockey Club

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine

Reference46 articles.

1. Steeg PS, Bevilacqua G, Pozzatti R, Liotta LA, Sobel ME (1988) Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 Ela inhibition of experimental metastasis. Cancer Res 48:6550–6554

2. Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker E, Margulies IM, King CR, Liotta LA, Steeg PS (1989) Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. Nature 342:177–180. https://doi.org/10.1038/342177a0

3. Steeg PS, Bevilacqua G, Sobel ME, Liotta LA (1991) Identification and characterization of differentially expressed genes in tumor metastasis: the nm23 gene. Basic Life Sci 57:355–360

4. Boissan M, Dabernat S, Peuchant E, Schlattner U, Lascu I, Lacombe ML (2009) The mammalian Nm23/NDPK family: from metastasis control to cilia movement. Mol Cell Biochem 329:51–62. https://doi.org/10.1007/s11010-009-0120-7

5. Ma D, McCorkle JR, Kaetzel DM (2004) The metastasis suppressor NM23-H1 possesses 3'-5' exonuclease activity. J Biol Chem 279:18073–18084. https://doi.org/10.1074/jbc.M400185200

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