Determining KRAS4B-Targeting Compound Specificity by Top–Down Mass Spectrometry-Reference-Cited by-同舟云学术

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Determining KRAS4B-Targeting Compound Specificity by Top–Down Mass Spectrometry

Published:2024 Issue: Volume: Page:291-310
ISSN:1064-3745
Container-title:Methods in Molecular Biology
language:en
Short-container-title:

Author:

D’Ippolito Robert A.,Scheidemantle Grace M.,Rabara Dana,Abreu Blanco Maria,Ramakrishnan Nitya,Widmeyer Stephanie R. T.,Messing Simon,Turner David,Maciag Anna E.,Stephen Andrew G.,Esposito Dominic,McCormick Frank,Nissley Dwight V.,DeHart Caroline J.

Publisher

Springer US

Link

https://link.springer.com/content/pdf/10.1007/978-1-0716-3922-1_18

Reference24 articles.

1. Duenas ME, Peltier-Heap RE, Leveridge M et al (2023) Advances in high-throughput mass spectrometry in drug discovery. EMBO Mol Med 15:e14850

2. Campuzano ID, San Miguel T, Rowe T et al (2016) High-throughput mass spectrometric analysis of covalent protein-inhibitor adducts for the discovery of irreversible inhibitors: a complete workflow. J Biomol Screen 21:136–144

3. Canon J, Rex K, Saiki AY et al (2019) The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature 575:217–223

4. Fell JB, Fischer JP, Baer BR et al (2020) Identification of the clinical development candidate MRTX849, a covalent KRAS(G12C) inhibitor for the treatment of cancer. J Med Chem 63:6679–6693

5. Punekar SR, Velcheti V, Neel BG et al (2022) The current state of the art and future trends in RAS-targeted cancer therapies. Nat Rev Clin Oncol 19:637–655

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