Author:
Müller Andreas,Meier Martin
Abstract
AbstractRenal length and volume are important parameters in the clinical assessment of patients with diabetes mellitus, kidney transplants, or renal artery stenosis. Kidney size is used in primary diagnostics to differentiate between acute (rather swollen kidneys) and chronic (rather small kidney) pathophysiology. Total kidney volume is also an established biomarker in studies for the treatment of autosomal dominant polycystic kidney disease (ADPKD). There are several factors influencing kidney size, and there is still a debate on the value of the measured kidney size in terms of renal function or cardiovascular risk. The renal volume is most often calculated by measuring the three axes of the kidney, on the assumption that the organ resembles an ellipsoid. By default, the longitudinal and transverse diameters of the kidney are measured. In animal models renal length and volume1 are also important parameters in the assessment of organ rejection after transplantation and in determination of kidney failure due to renal artery stenosis, recurrent urinary tract infections, or diabetes mellitus. In general total kidney volume (TKV) is a valuable parameter for predicting prognosis and monitoring disease progression in animal models of human diseases like polycystic kidney disease (PKD) or acute kidney injury (AKI) and chronic kidney disease (CKD).This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol is complemented by two separate chapters describing the basic concept and experimental procedure.
Reference6 articles.
1. King BF, Reed JE, Bergstralh EJ, et al (2000) Quantification and longitudinal trends of kidney, renal cyst, and renal parenchyma volumes in autosomal dominant polycystic kidney disease. 11:1505–1511
2. Sise C, Kusaka M, Wetzel LH et al (2000) Volumetric determination of progression in autosomal dominant polycystic kidney disease by computed tomography. Kidney Int 58:2492–2501
3. Grantham JJ, Torres VE (2016) The importance of total kidney volume in evaluating progression of polycystic kidney disease. Nat Rev Nephrol 12:667–677
4. Hederström E, Forsberg L (1985) Kidney size in children assessed by ultrasonography and urography. Acta Radiol Diagn (Stockh) 26:85–91
5. Ferrer FA, McKenna PH, Bauer MB et al (1997) Accuracy of renal ultrasound measurements for predicting actual kidney size. J Urol 157:2278–2281
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献