The relationship between debrisoquine oxidation phenotype and the pharmacokinetics of chlorpropamide
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/BF02657068.pdf
Reference16 articles.
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2. Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, Nebert DW, Gelboin HV, Hardwick JR Meyer UA (1988) Char- acterization of common genetic defect in humans deficient in de- brisoquine metabolism. Nature 331:442–446
3. Jacqz E, Hall SD, Branch RA (1986) Genetically determined polymorphisms in drug oxidation. Hepatology 6:1020–1032
4. Kalow W (1987) Genetic variation in the human hepatic cyto- chrome P-450 system. Eur J Clin Pharmaco1 31:633–641
5. Huupponen R, Lammintausta R (1981) Chlorpropamide bioavailability and pharmacokinetics. Int J Clin Pharmacol 19: 331–333
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1. Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism;British Journal of Clinical Pharmacology;2005-05
2. Clinical Pharmacology of Sulfonylureas;Oral Antidiabetics;1996
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