Reactive Oxygen-induced Carcinogenesis Causes Hypermethylation of p16Ink4a and Activation of MAP Kinase

Author:

Govindarajan Baskaran,Klafter Robert,Miller Mark Steven,Mansur Claire,Mizesko Melissa,Bai Xianhe,LaMontagne Kenneth,Arbiser Jack L.

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine

Reference47 articles.

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2. Driscoll KE, Carter JM, Howard BW, et al. (1998) Crocidolite activates NF-kappa B and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochrondrial-derived oxidants. Environ. Health Perspect.106Suppl 5: 1171–1174.

3. Meyskens FL, Jr, Buckmeier JA, McNulty SE, Tohidian NB. (1999) Activation of nuclear factor-kappa B in human metastatic melanomacells and the effect of oxidative stress. Clin. Cancer Res. 5: 1197–1202.

4. Tanaka T, Iwasa Y, Kondo S, et al. (1999) High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats. Oncogene 18: 3793–3797.

5. Costa M, Mollenhauer HH. (1980) Phagocytosis of nickel subsulfide particles during the early stages of neoplastic transformation in tissue culture. Cancer Res. 40: 2688–2694.

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