Differential molecular markers of primary lung tumors and metastatic sites indicate different possible treatment selections in patients with metastatic lung adenocarcinoma

Author:

Deng L.-L.,Deng H.-B.,Lu C.-L.,Gao G.,Wang F.,Yang Y.ORCID

Funder

Postdoctoral Scientific Research Developmental Fund of Heilongjiang Postdoctoral Program, China

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine

Reference35 articles.

1. An N, Yang X. Identification of prognostic genes through expression differentiation during metastatic process in lung adenocarcinoma. Sci Rep. 2017;7(1):11119. https://doi.org/10.1038/s41598-017-11520-6 .

2. Song Z, Yu X, Zhang Y. Clinicopathological characteristics and survival of ALK, ROS1 and RET rearrangements in non-adenocarcinoma non-small cell lung cancer patients. Cancer Biol Ther. 2017;18(11):883–7. https://doi.org/10.1080/15384047.2016.1235660 .

3. Ko R, Kenmotsu H, Serizawa M, Koh Y, Wakuda K, Ono A, et al. Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients. BMC Cancer. 2016;16(1):864. https://doi.org/10.1186/s12885-016-2902-0 .

4. Wu YL, Saijo N, Thongprasert S, Yang JC, Han B, Margono B, et al. Efficacy according to blind independent central review: post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC. Lung Cancer. 2017;104:119–25. https://doi.org/10.1016/j.lungcan.2016.11.022 .

5. Douillard JY, Shepherd FA, Hirsh V, Mok T, Socinski MA, Gervais R, et al. Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial. J Clin Oncol. 2010;28(5):744–52. https://doi.org/10.1200/JCO.2009.24.3030 .

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