Abstract
Abstract
Introduction
Penile carcinomas are rare tumors throughout Europe. Therefore, little attention is drawn to this disease. That makes it important to study tumor-associated key metrics and relate these to known data on penile neoplasias.
Materials and methods
A cohort of 60 well-defined penile invasive carcinomas with known human papillomavirus (HPV) infection status was investigated. Data on tumor type, grading and staging were recorded. Additionally, data on the peri- and intratumoral immune cell infiltrate in a semiquanititave manner applying an HE stain were assessed.
Results
Our study showed a significant correlation of immune cell infiltrate and pT stage with overall survival. Therefore, in a subset of tumors, PD-L1 staining was applied. For tumor proportion score (TPS), 26 of 30 samples (87%) were scored >0%. For the immune cell score (IC), 28 of 30 samples (93%) were defined as >0% and for CPS, 29 of 30 samples (97%) scored >0. PD-L1 expression was not associated with overall survival.
Conclusion
PD-L1 is expressed in penile carcinomas, providing a rationale for targeted therapy with checkpoint inhibitors. We were able to show that immune reaction appears to be prognostically relevant. These data enhance the need for further studies on the immune cell infiltrate in penile neoplasias and show that PD-L1 expression is existent in our cohort, which may be a potential target for checkpoint inhibitor therapy.
Funder
Universitätsklinikum Frankfurt
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,General Medicine
Reference40 articles.
1. Montes Cardona CE, García-Perdomo HA. Incidence of penile cancer worldwide: systematic review and meta-analysis. Rev Panam Salud Publica. 2017;41:117. https://doi.org/10.2663/RPSP.2017.117.
2. Sievert KD, Dräger DL, Köhn FM, Milerski S, Protzel C, Hakenberg OW. Penile cancer: diagnosis and staging. Urologe. 2018. https://doi.org/10.1007/s00120-018-0602-x.
3. Stratton KL (2016) MDJCMFM. A contemporary review of HPV and Penile Cancer. https://www.cancernetwork.com/oncology-journal/contemporary-review-hpv-and-penile-cancer/page/0/1
4. Yu YB, Wang YH, Yang XC, Zhao Y, Wang ML, Liang Y, Niu HT. The relationship between human papillomavirus and penile cancer over the past decade: a systematic review and meta-analysis. Asian J Androl. 2019;21:375–80. https://doi.org/10.4103/aja.aja_39_19.
5. Kobayashi K, Hisamatsu K, Suzui N, Hara A, Tomita H, Miyazaki T. A review of HPV-related head and neck cancer. J Clin Med. 2018;7:241. https://doi.org/10.3390/jcm7090241.
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献