Phase I metabolic profiling of the synthetic cannabinoids THJ-018 and THJ-2201 in human urine in comparison to human liver microsome and cytochrome P450 isoenzyme incubation-Reference-Cited by-同舟云学术

Phase I metabolic profiling of the synthetic cannabinoids THJ-018 and THJ-2201 in human urine in comparison to human liver microsome and cytochrome P450 isoenzyme incubation

Published:2018-12-18 Issue:4 Volume:133 Page:1049-1064
ISSN:0937-9827
Container-title:International Journal of Legal Medicine
language:en
Short-container-title:Int J Legal Med

Author:

Gaunitz Franziska,Thomas Andreas,Fietzke Mathias,Franz Florian,Auwärter Volker,Thevis Mario,Mercer-Chalmers-Bender Katja

Funder

Bundesministerium für Wirtschaft und Technologie

B.A.D.S.

Publisher

Springer Science and Business Media LLC

Subject

Pathology and Forensic Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00414-018-1964-8.pdf

Reference18 articles.

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2. Wintermeyer A, Möller I, Thevis M, Jübner M, Beike J, Rothschild MA, Bender K (2010) In vitro phase I metabolism of the synthetic cannabimimetic JWH-018. Anal Bioanal Chem 398(5):2141–2153. https://doi.org/10.1007/s00216-010-4171-0

3. Sobolevsky T, Prasolov I, Rodchenkov G (2012) Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids. Drug Test Anal 4(10):745–753. https://doi.org/10.1002/dta.1418

4. Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH (2012) Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands. Drug Metab Dispos 40(11):2174–2184. https://doi.org/10.1124/dmd.112.047530

5. Chimalakonda KC, Moran CL, Kennedy PD, Endres GW, Uzieblo A, Dobrowolski PJ, Fifer EK, Lapoint J, Nelson LS, Hoffman RS, James LP, Radominska-Pandya A, Moran JH (2011) Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine. Anal Chem 83(16):6381–6388. https://doi.org/10.1021/ac201377m

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