Abstract
Abstract
Background/purpose
Many studies suggest that insulin resistance in obese patients bridges mental illness. Our objective was to identify the association between levels of depression and anxiety with insulin resistance, and its relationship with obesity and abdominal obesity
Methods
A cross-sectional analytical study was carried out in Honduras. Sociodemographic variables, anthropometric parameters, HOMA index, and level of severity of anxiety and depression were collected, and a descriptive, bivariate, and multivariate were performed.
Results
In a sample of 381 adult patients, the bivariate analysis showed a statistic association of insulin resistance with all remaining variables. However, multivariate analysis showed a significative association of anxiety with BMI, depression, waist circumference, and insulinemia, while depression was associated with HOMA, anxiety, insulinemia, glycemia, and waist circumference.
Conclusions
Our results provide important evidence of a direct and growing association between HOMA-IR and the severity of depression, and indirectly with anxiety. Secondarily, also with anthropometric factors (BMI and WC), traditionally associated with cardiovascular risk. This finding has important implications both for the early diagnosis of these mental pathologies, taking into account HOMA-IR values, and for preventive interventions focused on maintaining blood insulin levels.
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference39 articles.
1. Hiles SA, Révész D, Lamers F, Giltay E, Penninx BWJH. Bidirectional prospective associations of metabolic syndrome components with depression, anxiety, and antidepressant use. Depress Anxiety. 2016;33(8):754–64. https://doi.org/10.1002/da.22512.
2. Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG, Pothos EN, Kahn CR. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. PNAS. 2015;112:3463–8. https://doi.org/10.1073/pnas.1500877112.
3. WHO. La OMS revela las principales causas de muerte y discapacidad en el mundo: 2000-2019. n.d.. WHO. Retrieved April 19, 2021, from https://www.who.int/es/news/item/09-12-2020-who-reveals-leading-causes-of-death-and-disability-worldwide-2000-2019
4. OPS/OMS Honduras - OPS/OMS Honduras. n.d.. OPS, 2020. Retrieved March 23, 2021, from https://www.paho.org/hon/index.php?option=com_content&view=article&id=1359:gobierno-y-ops-oms-promueven-estilos-de-vida-saludable-en-fuerza-laboral&Itemid=0
5. Bocicor AE, Buicu G, Varga A, Tatar R, Daniela S, Tilea I, Gabos-Grecu I. Association between increased waist circumference and depression and anxiety trend. Acta Med Marisiensis. 2015;61:87–90. https://doi.org/10.1515/amma-2015-0028.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献