Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart

Author:

Brunkhorst Detlef,v. der Leyen Heiko,Meyer Wilfried,Nigbur Rüdiger,Schmidt-Schumacher Carlos,Scholz Hasso

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference30 articles.

1. Alousi AA, Johnson DJ (1986) Pharmacology of the bipyridines: amrinone and milrinone. Circulation 73 (Suppl III):III-10-III-24

2. Berger C, Meyer W, Scholz H, Starbatty J (1985) Effects of the benzimidazole derivatives pimobendan and 2-(4-hydroxyphenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl) benzimidazole · HCI on phosphodiesterase activity and on force of contraction in guinea-pig hearts. Arzneimittelforschung 35:1668?1673

3. Bergstrand H, Kristoffersson J, Lundquist B, Schurmann A (1977) Effects of antiallergic agents, compound 48/80, some reference inhibitors on the activity of partially purified human lung tissue adenosine cyclic 3?,5?-monophosphate and guanosine cyclic 3?,5?-monophosphate phosphodiesterases. Mol Pharmacol 13: 38?43

4. Bethke Th, Brunkhorst D, v. der Leyen H, Meyer W, Nigbur R, Scholz H (1988) Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts. Naunyn-Schmiedeberg's Arch Pharmacol 337:576?582

5. Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248?254

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