Formation of reactive 1-nitropyrene metabolites by lung microsomes and isolated lung cells

Author:

Dybing Erik,Dahl Jon E.,Beland Frederick A.,Thorgeirsson Snorri S.

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Cell Biology,Toxicology

Reference32 articles.

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2. AUNE, T. VANDERSLICE, R.R., CROFT, J.E., DYBING, E., BEND, J.R. and PHILPOT, R.M. (1985b). Deacetylation to 2-aminofluorene as a major initial reaction in the microsomal metabolism of 2-acetylaminofluorene to mutagenic products in preparations from rabbit lung and liver. Cancer Res. 45:5859?5866.

3. AUNE, T. and TVEITO AUNE, K. (1986). Mutagenic activation of IQ and Me-IQ by liver and lung microsomes from the rabbit and mouse, and with isolated lung cells from rabbits. Carcinogenesis 7:273?276.

4. BEND, J.R., SERABJIT-SINGH, C.J. and PHILPOT, R.M. (1985). The pulmonary uptake, accumulation, and metabolism of xenobiotics. Ann. Rev. Pharmacol. Toxicol. 25:97?125.

5. BOND, J.A. and MAUDERLY, J.L. (1984). Metabolism and macromolecular covalent binding of [14C]-1-nitropyrene in isolated perfused and ventilated rat lungs. Cancer Res. 44:3924?3929.

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