Synthesis and biological activity of annulated pyrazoles as selective COX-2 inhibitors. I.

Author:

Kim Hyun Hee,Park Jae Gyu,Moon Tae Chul,Chang Hyun Wook,Jahng Yurngdong

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Drug Discovery,Molecular Medicine

Reference16 articles.

1. Chang, H. W., Jahng, Y., Selective cyclooxygenase-2 inhibitors as anti-inflammatory agents.J. Kor. Med. Chem., 8, 48–79 (1998), and references therein.

2. Giannangeli, M., Tomaselli, M., Pinza, M. Pharmaceutical compositions comprising diaryl-cyclomethylenepyrazole compounds and their use as cyclooxygenase II (COX II) inhibitors. WO, 9822442.

3. Graul, A., Martel, A. M., Castaner, J., Celecoxib, anti-inflammatory cyclooxygenase-2 inhibitor.Drugs of the Future, 22, 711–714 (1997).

4. Insel, P. A. InGoodmand and Gilman's The Pharmaceutical Basis of Therapeutics, 9th ed.; Hardman, J. G., Limbird, L. E.; Molinoff, P. B.; Ruddon, R. W., Gilman, A. G., eds., McGraw-Hill, New York, 617–658 (1996).

5. Jahng, Y. After submission of this paper, inhibitory activities of related 1,3-diaryl isomers were reported. Sui, Z., Guan, J., Ferro, M. P., McCoy, K., Wachter, M. P., Singer, M., Steber, M., Ritchie, D. M. Argentieri, D. C. 1,3-Diarylcycloalkaono[1,2-d]pyrazoles and diphenyl hydrazides as selective inhibitors of cyclo-oxygenase-2, 217th ACS National Meeting, Anaheim, CA, 1999, MEDI 202.

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