Author:
Nguyen Aivi T.,Kouri Naomi,Labuzan Sydney A.,Przybelski Scott A.,Lesnick Timothy G.,Raghavan Sheelakumari,Reid Robert I.,Reichard R. Ross,Knopman David S.,Petersen Ronald C.,Jack Clifford R.,Mielke Michelle M.,Dickson Dennis W.,Graff-Radford Jonathan,Murray Melissa E.,Vemuri Prashanthi
Abstract
AbstractSummarizing the multiplicity and heterogeneity of cerebrovascular disease (CVD) features into a single measure has been difficult in both neuropathology and imaging studies. The objective of this work was to evaluate the association between neuroimaging surrogates of CVD and two available neuropathologic CVD scales in those with both antemortem imaging CVD measures and postmortem CVD evaluation. Individuals in the Mayo Clinic Study of Aging with MRI scans within 5 years of death (N = 51) were included. Antemortem CVD measures were computed from diffusion MRI (dMRI), FLAIR, and T2* GRE imaging modalities and compared with postmortem neuropathologic findings using Kalaria and Strozyk Scales. Of all the neuroimaging measures, both regional and global dMRI measures were associated with Kalaria and Strozyk Scales (p < 0.05) and modestly correlated with global cognitive performance. The major conclusions from this study were: (i) microstructural white matter injury measurements using dMRI may be meaningful surrogates of neuropathologic CVD scales, because they aid in capturing diffuse (and early) changes to white matter and secondary neurodegeneration due to lesions; (ii) vacuolation in the corpus callosum may be associated with white matter changes measured on antemortem dMRI imaging; (iii) Alzheimer’s disease neuropathologic change did not associate with neuropathologic CVD scales; and (iv) future work should be focused on developing better quantitative measures utilizing dMRI to optimally assess CVD-related neuropathologic changes.
Funder
National Institutes of Health
Gerald and Henrietta Rauenhorst Foundation
Alzheimer's Drug Discovery Foundation
Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Foundation
Liston Award
Elsie and Marvin Dekelboum Family Foundation
Schuler Foundation
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology (clinical),Pathology and Forensic Medicine
Cited by
10 articles.
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