Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS-Reference-Cited by-同舟云学术

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Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS

Published:2016-02-19 Issue:4 Volume:131 Page:587-604
ISSN:0001-6322
Container-title:Acta Neuropathologica
language:en
Short-container-title:Acta Neuropathol

Author:

Suárez-Calvet Marc,Neumann Manuela,Arzberger Thomas,Abou-Ajram Claudia,Funk Eva,Hartmann Hannelore,Edbauer Dieter,Kremmer Elisabeth,Göbl Christoph,Resch Moritz,Bourgeois Benjamin,Madl Tobias,Reber Stefan,Jutzi Daniel,Ruepp Marc-David,Mackenzie Ian R. A.,Ansorge Olaf,Dormann Dorothee,Haass Christian

Funder

European Research Council (BE)

Deutsche Forschungsgemeinschaft (DE)

Emmy Noether Program

German Helmholtz Association

Instituto de Salud Carlos III (ES)

Bayerisches Staatsministerium für Wissenschaft, Forschung und Kunst (DE)

Deutsche Stiftung für Herzforschung (DE)

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Clinical Neurology,Pathology and Forensic Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00401-016-1544-2.pdf

Reference60 articles.

1. Araya N, Hiraga H, Kako K, Arao Y, Kato S, Fukamizu A (2005) Transcriptional down-regulation through nuclear exclusion of EWS methylated by PRMT1. Biochem Biophys Res Commun 329:653–660. doi: 10.1016/j.bbrc.2005.02.018

2. Bedford MT, Clarke SG (2009) Protein arginine methylation in mammals: who, what, and why. Mol Cell 33:1–13. doi: 10.1016/j.molcel.2008.12.013

3. Belyanskaya LL, Delattre O, Gehring H (2003) Expression and subcellular localization of Ewing sarcoma (EWS) protein is affected by the methylation process. Exp Cell Res 288:374–381

4. Belyanskaya LL, Gehrig PM, Gehring H (2001) Exposure on cell surface and extensive arginine methylation of Ewing Sarcoma (EWS) protein. J Biol Chem 276:18681–18687. doi: 10.1074/jbc.M011446200

5. Brelstaff J, Lashley T, Holton JL, Lees AJ, Rossor MN, Bandopadhyay R, Revesz T (2011) Transportin1: a marker of FTLD-FUS. Acta Neuropathol 122:591–600. doi: 10.1007/s00401-011-0863-6

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