Genome-wide association study and functional validation implicates JADE1 in tauopathy
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Published:2021-11-01
Issue:1
Volume:143
Page:33-53
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ISSN:0001-6322
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Container-title:Acta Neuropathologica
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language:en
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Short-container-title:Acta Neuropathol
Author:
Farrell Kurt, Kim SoongHo, Han Natalia, Iida Megan A., Gonzalez Elias M., Otero-Garcia Marcos, Walker Jamie M., Richardson Timothy E., Renton Alan E., Andrews Shea J., Fulton-Howard Brian, Humphrey Jack, Vialle Ricardo A., Bowles Kathryn R., de Paiva Lopes Katia, Whitney Kristen, Dangoor Diana K., Walsh Hadley, Marcora Edoardo, Hefti Marco M., Casella Alicia, Sissoko Cheick T., Kapoor Manav, Novikova Gloriia, Udine Evan, Wong Garrett, Tang Weijing, Bhangale Tushar, Hunkapiller Julie, Ayalon Gai, Graham Robert R., Cherry Jonathan D., Cortes Etty P., Borukov Valeriy Y., McKee Ann C., Stein Thor D., Vonsattel Jean-Paul, Teich Andy F., Gearing Marla, Glass Jonathan, Troncoso Juan C., Frosch Matthew P., Hyman Bradley T., Dickson Dennis W., Murray Melissa E., Attems Johannes, Flanagan Margaret E., Mao Qinwen, Mesulam M.-Marsel, Weintraub Sandra, Woltjer Randy L., Pham Thao, Kofler Julia, Schneider Julie A., Yu Lei, Purohit Dushyant P., Haroutunian Vahram, Hof Patrick R., Gandy Sam, Sano Mary, Beach Thomas G., Poon Wayne, Kawas Claudia H., Corrada María M., Rissman Robert A., Metcalf Jeff, Shuldberg Sara, Salehi Bahar, Nelson Peter T., Trojanowski John Q., Lee Edward B., Wolk David A., McMillan Corey T., Keene C. Dirk, Latimer Caitlin S., Montine Thomas J., Kovacs Gabor G., Lutz Mirjam I., Fischer Peter, Perrin Richard J., Cairns Nigel J., Franklin Erin E., Cohen Herbert T., Raj Towfique, Cobos Inma, Frost Bess, Goate Alison, White III Charles L., Crary John F.ORCID
Funder
National Institutes of Health Rainwater Charitable Foundation Genentech Alexander Saint-Amand Fellowship The Arizona Department of Health Services Michael J. Fox Foundation for Parkinson's Research Winspear Family Center for Research on the Neuropathology of Alzheimer Disease Rossy Foundation Edmond J. Safra Philanthropic Foundation Nancy and Buster Alvord Endowment UK Medical Research Council Brains for Dementia research Alzheimer’s Society and Alzheimer’s Research UK Newcastle upon Tyne Hospitals NHS Foundation Trust
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology (clinical),Pathology and Forensic Medicine
Reference107 articles.
1. Abner EL, Neltner JH, Jicha GA, Patel E, Anderson SL, Wilcock DM et al (2018) Diffuse amyloid-beta plaques, neurofibrillary tangles, and the impact of APOE in elderly persons’ brains lacking neuritic amyloid plaques. J Alzh Dis 64:1307–1324. https://doi.org/10.3233/Jad-180514 2. Aldridge GM, Podrebarac DM, Greenough WT, Weiler IJ (2008) The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting. J Neurosci Methods 172:250–254. https://doi.org/10.1016/j.jneumeth.2008.05.003 3. Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP, Zondervan KT (2010) Data quality control in genetic case-control association studies. Nat Protoc 5:1564–1573. https://doi.org/10.1038/nprot.2010.116 4. Andrews SJ, Fulton-Howard B, Goate A (2020) Interpretation of risk loci from genome-wide association studies of Alzheimer’s disease. Lancet Neurol 19:326–335. https://doi.org/10.1016/S1474-4422(19)30435-1 5. Augustinack JC, Schneider A, Mandelkow EM, Hyman BT (2002) Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer’s disease. Acta Neuropathol 103:26–35. https://doi.org/10.1007/s004010100423
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