Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo-Reference-Cited by-同舟云学术

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

Published:2019-02-05 Issue:4 Volume:137 Page:599-617
ISSN:0001-6322
Container-title:Acta Neuropathologica
language:en
Short-container-title:Acta Neuropathol

Author:

Stancu Ilie-Cosmin,Cremers Niels,Vanrusselt Hannah,Couturier Julien,Vanoosthuyse Alexandre,Kessels Sofie,Lodder Chritica,Brône Bert,Huaux François,Octave Jean-Noël,Terwel Dick,Dewachter Ilse

Funder

Fondation pour la Recherche Alzheimer

Fonds De La Recherche Scientifique - FNRS

Agentschap Innoveren en Ondernemen

Fonds Wetenschappelijk Onderzoek

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Clinical Neurology,Pathology and Forensic Medicine

Link

http://link.springer.com/article/10.1007/s00401-018-01957-y/fulltext.html

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3. Audouard E, Houben S, Masaracchia C, Yilmaz Z, Suain V, Authelet M et al (2016) High-molecular-weight paired helical filaments from Alzheimer brain induces seeding of wild-type mouse Tau into an argyrophilic 4R Tau pathology in vivo. Am J Pathol 186:2709–2722. https://doi.org/10.1016/j.ajpath.2016.06.008

4. Baroja-Mazo A, Martin-Sanchez F, Gomez AI, Martinez CM, Amores-Iniesta J, Compan V et al (2014) The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol 15:738–748. https://doi.org/10.1038/ni.2919

5. Bellucci A, Bugiani O, Ghetti B, Spillantini MG (2011) Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation. Neurodegener Dis 8:221–229. https://doi.org/10.1159/000322228

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