MK-208, a novel histamine H2-receptor inhibitor with prolonged antisecretory effect

Author:

McCallum Richard W.,Chremos A. N.,Kuljian Bonnie,Tupy-Visich M. A.,Huber P. B.

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology,Physiology

Reference11 articles.

1. Black JW, Duncan WAM, Durant CJ, Ganellin CR, Parsons EM: Definition and antagonism of histamine H2 receptors. Nature 236:385, 1972

2. Takeda M, Takage T, Maeno H: Effect of a new potent H2 blocker, 3-({[2-diaminomethylene)amino]-4-thiazolyl}methyl)thio-N 2-sulfamoylpropionamidine (YM-11170), on gastric secretion, ulcer formation, and weight of male accessory sex organs in rats. Arzneim Forsch 32:734?737, 1982

3. Takage T, Takeda M, Maeno H: Effect of a new potent H2 blocker, 3-({[2-diaminomethylene)amino]-4-thiazolyl}methyl)thio-N 2-sulfamoylpropionamidine (YM-11170), on gastric secretion induced by histamine and food in conscious dogs. Arch Int Pharmacodyn Ther 256:49?58, 1982

4. Pendleton RG, Torchiana ML, Chung C, Cook P, Wiese S, Clineschmidt BV: Studies on MK-208 (YM-11170) a new slowly dissociable H2-receptor antagonist. Arch Int Pharmacodyn Ther 266:4?16, 1983

5. Smith JL, Chremos AN, Gamal M, Graham DY: Gastric antisecretory effects in man of a novel H2-receptor inhibitor 3-({[2-diaminomethylene)amino]-4-thiazolyl}methyl)thio-N 2-sulfamoylpropionamidine (MK-208). Clin Pharm Ther 33:216, 1983

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