Clinical Effects from Ingestion of Lappaconitine, an Aconitum Alkaloid with Sodium Channel Blocking Effects
Author:
Funder
University of Iowa Hospitals and Clinics
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology
Link
https://link.springer.com/content/pdf/10.1007/s13181-022-00896-1.pdf
Reference37 articles.
1. Doering NA, et al. A copper-mediated conjugate addition approach to analogues of aconitine-type diterpenoid alkaloids. J Org Chem. 2018;83(20):12911–20.
2. Wright SN. Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine. Mol Pharmacol. 2001;59(2):183–92.
3. Valeev AE, Verkhratskiĭ AN, Dzhakhangirov FN. The effect of allapinine on the sodium currents of isolated trigeminal ganglion neurons and cardiomyocytes of rats. Neirofiziologiia. 1990;22(2):201–6.
4. Heubach JF, Schüle A. Cardiac effects of lappaconitine and N-deacetyllappaconitine, two diterpenoid alkaloids from plants of the Aconitum and Delphinium species. Planta Med. 1998;64(1):22–6.
5. Wang SY, Wang GK. Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cell Signal. 2003;15(2):151–9.
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