Selective Induction of Cellular Toxicity and Anti-tumor Efficacy by N-Methylpiperazinyl Diarylidenylpiperidone and its Pro-nitroxide Conjugate through ROS-mediated Mitochondrial Dysfunction and G2/M Cell-cycle Arrest in Human Pancreatic Cancer-Reference-Cited by-同舟云学术

Selective Induction of Cellular Toxicity and Anti-tumor Efficacy by N-Methylpiperazinyl Diarylidenylpiperidone and its Pro-nitroxide Conjugate through ROS-mediated Mitochondrial Dysfunction and G2/M Cell-cycle Arrest in Human Pancreatic Cancer

Published:2020-05-24 Issue:2 Volume:78 Page:191-202
ISSN:1085-9195
Container-title:Cell Biochemistry and Biophysics
language:en
Short-container-title:Cell Biochem Biophys

Author:

Mast Jesse M.,Hinds John W.,Tse Dan,Axelrod Katherine,Kuppusamy M. Lakshmi,Kmiec Maciej M.,Bognár Balázs,Kálai Tamás,Kuppusamy Periannan^ORCID

Funder

National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Biochemistry,General Medicine,Biophysics

Link

https://link.springer.com/content/pdf/10.1007/s12013-020-00919-0.pdf

Reference34 articles.

1. Seer, N. Cancer stat facts: pancreatic cancer. 2015; Available from: https://seer.cancer.gov/statfacts/html/pancreas.html.

2. Gordon-Dseagu, V. L., Devesa, S. S., Goggins, M., & Stolzenberg-Solomon, R. (2018). Pancreatic cancer incidence trends: evidence from the Surveillance, Epidemiology and End Results (SEER) population-based data. International Journal of Epidemiology, 47(2), 427–439.

3. Conroy, T., Desseigne, F., Ychou, M., Bouche, O., Guimbaud, R., Becouarn, Y., Adenis, A., Raoul, J. L., Gourgou-Bourgade, S., de la Fouchardiere, C., Bennouna, J., Bachet, J. B., Khemissa-Akouz, F., Pere-Verge, D., Delbaldo, C., Assenat, E., Chauffert, B., Michel, P., Montoto-Grillot, C., & Ducreux, M. Groupe Tumeurs Digestives of Unicancer and the PRODIGE Intergroup (2011). FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. The New England Journal of Medicine, 364(19), 1817–1825.

4. Abdullah, L. N., & Chow, E. K. (2013). Mechanisms of chemoresistance in cancer stem cells. Clinical and Translational Medicine, 2(1), 3.

5. Cheung-Ong, K., Giaever, G., & Nislow, C. (2013). DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology. Chemistry and Biology, 20(5), 648–659.

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