Emetine induces estrogen receptor alpha degradation and prevents 17β-estradiol-induced breast cancer cell proliferation
Author:
Funder
Associazione Italiana per la Ricerca sul Cancro (IT)
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine,General Medicine
Link
http://link.springer.com/article/10.1007/s13402-017-0322-z/fulltext.html
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2. D.P. McDonnell, S.E. Wardell, J.D. Norris, Oral selective estrogen receptor Downregulators (SERDs), a breakthrough endocrine therapy for breast cancer. J. Med. Chem. 58, 4883–4887 (2015)
3. P. Totta, C. Busonero, S. Leone, M. Marino, F. Acconcia, Dynamin II is required for 17beta-estradiol signaling and autophagy-based ERalpha degradation. Sci. Rep. 6, 23727 (2016)
4. F. Acconcia, M. Fiocchetti, M. Marino, Xenoestrogen regulation of ERalpha/ERbeta balance in hormone-associated cancers. Mol. Cell. Endocrinol. (2016) doi: 10.1016/j.mce.2016.10.033
5. P.K. Mehrotra, S. Kitchlu, A. Dwivedi, P.K. Agnihotri, S. Srivastava, R. Roy, A.P. Bhaduri, Emetine ditartrate: A possible lead for emergency contraception. Contraception 69, 379–387 (2004)
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