Irreversible Enzyme Inhibition Kinetics and Drug–Drug Interactions

Author:

Mohutsky Michael,Hall Stephen D.

Publisher

Humana Press

Reference100 articles.

1. Renton KW (1985) Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil. Biochem Pharmacol 34(14):2549–2553, 0006-2952(85)90541-6 [pii]

2. Mousa O, Brater DC, Sunblad KJ, Hall SD (2000) The interaction of diltiazem with simvastatin. Clin Pharmacol Ther 67(3):267–274. doi: 10.1067/mcp.2000.104609 , S0009923600965603 [pii]

3. Jones DR, Gorski JC, Hamman MA, Mayhew BS, Rider S, Hall SD (1999) Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation. J Pharmacol Exp Ther 290(3):1116–1125

4. Sutton D, Butler AM, Nadin L, Murray M (1997) Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. J Pharmacol Exp Ther 282(1):294–300

5. Zhang X, Quinney SK, Gorski JC, Jones DR, Hall SD (2009) Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite. Drug Metab Dispos 37(8):1587–1597. doi: 10.1124/dmd.109.026658 , dmd.109.026658 [pii]

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