Invasive Fungal Rhinosinusitis Due to Co-infection with Mucormycosis and Exserohilum rostratum in a Patient with Acute Lymphoblastic Leukemia-Reference-Cited by-同舟云学术

Invasive Fungal Rhinosinusitis Due to Co-infection with Mucormycosis and Exserohilum rostratum in a Patient with Acute Lymphoblastic Leukemia

Published:2022-06 Issue:1-2 Volume:4 Page:60-64
ISSN:2590-0048
Container-title:Clinical Hematology International
language:en
Short-container-title:Clin Hematol Int

Author:

Radici Vera,Brissot Eolia,Chartier Suzanne,Guitard Juliette,Fabiani Bettina,Memoli Mara,Banet Anne,Heuberger Laurence,Lapusan Simona,Atallah Sarah,Legrand Ollivier,Genthon Alexis^ORCID

Abstract

AbstractInvasive fungal infections remain an important cause of complication and morbidity in the management of acute leukemias. Here we report the case of a 27-year-old patient from French Polynesia who was diagnosed with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia. After induction chemotherapy, she developed rhinosinusitis with extensive bone lysis. The context and clinical presentation quickly made us suspect an invasive mucormycosis infection. However, a multidisciplinary investigation including mass spectrometry techniques also revealed the presence of Exserohilum rostratum, a pathogen member of the genus Exserohilum that is ubiquitous in tropical and subtropical regions but rarely implicated in invasive sinusitis. Antifungal treatment combined with an early surgical approach resulted in a favorable clinical response.

Publisher

AquacultureHub

Subject

Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics

Link

https://link.springer.com/content/pdf/10.1007/s44228-022-00009-3.pdf

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