Brain Abscesses in the Tropics
Author:
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Immunology and Allergy
Link
https://link.springer.com/content/pdf/10.1007/s40475-023-00306-8.pdf
Reference60 articles.
1. •• Bodilsen J, et al. Risk factors for brain abscess: a nationwide, population-based, nested case-control study. Clin Infect Dis. 2020;71(4):1040–6. A population-based study involving 1,384 brain abscess patients revealed major risk factors: neurosurgery (aOR 19.3), congenital heart disease (aOR 15.6), dental infections (aOR 4.61), and ear, nose, and throat infections (aOR 3.81). Among patients, significant associations with brain abscess occurrence included hematological cancer (aOR 8.77), immunomodulating treatments (aOR 5.71), and conditions like diabetes, alcohol abuse, and liver disease.
2. • Bodilsen J, et al. Clinical features and prognostic factors in adults with brain abscess. Brain. 2023;146(4):1637–47. A study of 485 cases highlighted the increasing incidence of brain abscesses in adults and identified key mortality risk factors, including brain abscess rupture and immunocompromise. The research suggests delaying antibiotics in select cases awaiting neurosurgery within 24 hours and found no increased mortality risk with corticosteroids for brain edema.
3. Cantiera M, Tattevin P, Sonneville R. Brain abscess in immunocompetent adult patients. Rev Neurol (Paris). 2019;175(7–8):469–74.
4. Mendes M, et al. Susceptibility of brain and skin to bacterial challenge. J Neurosurg. 1980;52(6):772–5.
5. •• Stebner A, et al. Molecular diagnosis of polymicrobial brain abscesses with 16S-rDNA-based next-generation sequencing. Clin Microbiol Infect. 2021;27(1):76–82. A study utilizing 16S-rRNA-based next-generation sequencing (NGS) to identify bacteria in intracranial abscesses and meningitis samples, aiming to overcome the limitations of culture-based methods and traditional molecular diagnostics in detecting the diverse bacterial causes. Using NGS, 86 bacterial taxa were identified in brain abscesses with Streptococcus intermedius and Fusobacterium nucleatum as the most common. The study underscores the often polymicrobial nature of these infections, detecting up to 16 different bacterial taxa in a single sample, and establishes the MiSeq platform’s effectiveness for metagenomic diagnostics of such severe infections.
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