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Reference31 articles.
1. Borel JF, Feurer C, Gubler HU, et al.: Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Actions 1976, 6:468–475. This is a historic article worthy of reading, which demonstrates how findings at the bench and in rat models eventually find themselves transferred to the bedside. Of special interest are the observations (speculations) that Borel had about the mechanism of action of cyclosporine.
2. Calne R, Rolles K, White DJ, et al.: Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs. Lancet 1979, 2:1033–1036. This article describes a not-so-good experience in humans with cyclosporine. However, it was an experience with 34 patients that prompted further study by Starzl et al. [4].
3. Ryffel B, Siegl H, Petric R, et al.: Nephrotoxicity of cyclosporine in spontaneously hypertensive rats: effects on blood pressure and vascular lesions. Clin Nephrol 1986, 25(Suppl 1):S193-S198.
4. Starzl TE, Weil R, Iwatsuki S, et al.: The use of cyclosporin A and prednisone in cadaver kidney transplantation. Surg Gynecol Obstet 1980, 151:17–26.
5. Palestine AG, Nussenblatt RB, Chan CC: Side effects of systemic cyclosporine in patients not undergoing transplantation. Am J Med 1984, 77:652–656. This study established the undesired effects and nephrotoxicity of cyclosporine in a group of nontransplant patients. Prior consideration of side effects in transplanted patients could never be as certain of the causal role of cyclosporine because of other drugs and other renal conditions.
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